A Novel Capless Self-Amplifying RNA Platform and its Applications
Abstract
This study introduces a novel capless self-amplifying mRNA (CLsamRNA) platform featuring a unique viral replicon and internal ribosome entry site, simplifying vaccine production by removing the need for capping. CLsamRNA significantly enhanced antigen expression both in vitro and in vivo. Immunization with just 0.01 μg CLsamRNA encoding H5 hemagglutinin induced neutralizing antibodies providing complete protection against lethal H5N8 virus challenge in mice. CLsamRNA-based vaccines targeting canine influenza and severe fever with thrombocytopenia syndrome virus (SFTSV) similarly elicited robust neutralizing antibodies across diverse animal models. Additionally, a vaccine targeting HPV-induced cancer achieved complete tumor suppression. This potent, cost-effective platform shows substantial promise for rapid vaccine development and versatile therapeutic applications.
Prof Min-Suk Song
Min-Suk Song, Ph.D., is a Professor at Chungbuk National University Medical School in the Republic of Korea. Specializing in microbiology, his research focuses on influenza virus pathogenesis and infectious disease vaccine development. Dr. Song completed his B.S. (2006), M.S. (2008), and Ph.D. (2011) at Chungbuk National University, followed by postdoctoral research at St. Jude Children's Research Hospital (2013-2014). He leads innovative projects using a capless self-amplifying RNA vaccine platform and actively participates in national and international virology societies.
Prof Min-Suk Song, Queensland Alliance for Agriculture and Agriculture and Food Innovation E: songminsuk@chungbuk.ac.kr
For any questions, please contact the QAAFI Science Seminar Committee.
For any questions, please contact the QAAFI Science Seminar Committee.
About Science Seminars
Queensland Alliance for Agriculture and Food Innovation hosts science seminars across the disciplines of animal, horticulture, crop, food and nutritional sciences.
With a range of speakers from Australia and abroad, the series explores how high-impact science will significantly improve the competitiveness and sustainability of the tropical and sub-tropical food, fibre and agribusiness sectors.
View Science Seminar pageSign up to receive QAAFI Science Seminar notifications
Email Science Seminar Committee
The Queensland Alliance for Agriculture and Food Innovation is a research institute at The University of Queensland supported by the Queensland Government via the Queensland Department of Agriculture and Fisheries.