Glycogen is a polysaccharide molecule that stores glucose in animals, fungi, and E.coli. Glycogen biosynthesis starts on an oligosaccharide chain primed by glycogenin, elongated by glycogen synthase and branched via glycogen branching enzyme. Traditionally, glycogenin is believed to be essential for glycogen synthesis and structure formation. However, a recent study on glycogenin knockout mice found that glycogen formation still occurs in skeletal muscle, liver, cardiac muscle, and brain. The study also revealed structural and physiological results that contradict the expected role of glycogenin in linking β particles into α particles. This research aims to explore glycogenin's function in the liver through proteomic investigation on Gyg KO mice and targeted glycogen structure characterization and selected metabolites biochemical quantification. The results suggest glycogenin is dispensible for liver tissue. There is only minor metabolism change in Gyg KO mice liver.

Dr Xinle Tan

I obtained my PhD in molecular biology from SCMB, UQ. My first postdoc is about synthetic biology with Professor Robert Speight. currently I am doing my second postdoc with Professor Eugeni Roura. my personal interest is to reveal life metabolism from system biology point of view. my current research focous on animal taste/nutrition mechanism, mainly in chickena and pig.

Dr Xinle Tan, Post-Doctoral Research Fellow, Centre for Animal Science, Queensland Alliance for Agriculture and Food Innovation E: xinle.tan@uq.edu.au

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Queensland Alliance for Agriculture and Food Innovation hosts science seminars across the disciplines of animal, horticulture, crop, food and nutritional sciences.

With a range of speakers from Australia and abroad, the series explores how high-impact science will significantly improve the competitiveness and sustainability of the tropical and sub-tropical food, fibre and agribusiness sectors.

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The Queensland Alliance for Agriculture and Food Innovation is a research institute at The University of Queensland supported by the Queensland Government via the Queensland Department of Agriculture and Fisheries.


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