Game-changing spray to revolutionise pest control

17 May 2022

An environmentally friendly spray that targets and kills one of cotton's (and the world’s) most damaging agricultural pests - silverleaf whitefly - has been created by scientists at The University of Queensland.

The breakthrough is part of UQ’s BioClay™ technology, a safe and sustainable alternative to chemical pesticides, which has been developed over the past decade by Queensland Alliance for Agriculture and Food Innovation (QAAFI) and the Australian Institute for Bioengineering and Nanotechnology (AIBN), with support from CRDC, Hort Innovation and Nufarm Ltd.

Research team leader Professor Neena Mitter said it was a game-changer for crop protection because it was effective against whitefly (Bemisia tabaci), a small insect responsible for the loss of billions of dollars in agricultural crops around the world.

“Silverleaf whitefly (SLW) is considered an invasive species in the United States, Australia, Africa and several European countries and attacks more than 500 plant species including cotton, pulses, chilli, capsicum, and many other vegetable crops,” Professor Mitter said.

“The insect lays eggs on the underside of the leaves and the nymphs and adults suck the sap from the plant resulting in reduced yields.”

In addition, whiteflies also transmit many viruses which pose a threat to healthy crops.

Control of the pest has been difficult due to its ability to quickly develop resistance to traditional chemical pesticides.

The BioClay spray uses degradable clay particles that carry double-stranded RNA which enters the plant and protects it without altering the plant’s genome.

“It is the first time the BioClay platform has been used to target sap sucking insect pests,” Professor Mitter said.

“When whiteflies try to feed on the sap, they also ingest the dsRNA, which kills the insect by targeting genes essential to its survival.

“The world of RNA is not just responsible for COVID-19 vaccines, it will also revolutionise the agricultural industry by protecting plants from viruses, fungi and insect pests,” she said.

To identify suitable gene targets, PhD candidate Ritesh Jain went through the global database of genome sequences.

“Initially, we had to screen hundreds of genes specific to SLW to see which ones would affect their growth,” Mr Jain said.

“Importantly, the dsRNA proved harmless when fed to other insects, such as stingless bees and aphids.”

CRDC’s Senior R&D Manager, Susan Maas says SLW is a major pest of cotton globally due to its ability to contaminate and downgrade lint quality.

“This innovation will support the industry to maintain Australia’s reputation for producing uncontaminated, high-quality cotton in a safe and environmentally friendly way” Ms Maas said.

Hort Innovation research and development manager, Dr Vino Rajandran said the spray could give the industry another tool in its biosecurity armoury. 

“It has the potential to save growers time and money and is a great example of industry levy investment in action,” Dr Rajandran said.

The researchers will now work with industry partner Nufarm Ltd to test the whitefly BioClay formulation in real-world production systems.

Nufarm’s Global Lead for Transformational Projects, Mike Pointon said the company was “proud to be partnering with these world-leading scientists to develop cutting-edge technologies that bring new, alternative control options to farmers.”

The research is published in Nature Plants.

The work has been supported by a Horticulture Innovation Australia grant, with the Cotton Research and Development Corporation, Nufarm, the University of Queensland and the Queensland Government via the Department of Agriculture and Fisheries.


Research contacts: Professor Neena Mitter,, +61 (0)434 628 094 or Mr Ritesh Jain,, +61 (0)469 874 054.
Media contacts: Carolyn Martin, QAAFI Media or +61 (0)439 399 886 or UQ media,, +61 (0)429 056 139.
Download photos and a video from Dropbox. Photos used should acknowledge UQ and captions are available on request.  ​​
The browser image on this webpage is by Renee Anderson and shows a young cotton crop near Emerald in Queensland.
Ritesh Jain and Professor Neena Mitter

Australian scientists Ritesh Jain (L) and Professor Neena Mitter say tests using BioClayTM on cotton plants are harmless to other insects including the stingless bee (Tetragonula hockingsi) and aphid (Myzus persicae), photo by Megan Pope UQ.

UQ QAAFI research team for sustainable crop protection
UQ QAAFI research team for sustainable crop protection (photo by Megan Pope UQ)

The Queensland Alliance for Agriculture and Food Innovation is a research institute at The University of Queensland supported by the Queensland Government via the Queensland Department of Agriculture and Fisheries.