Dr Tanya McDonald
Principal Facilities and Safety Coordinator
Queensland Alliance for Agriculture and Food Innovation
+61 7 344 34926
Book Chapters
Han, Felicity Y., McDonald, Tanya, Xu, Weizhi and Borges, Karin (2021). Alterations in mitochondrial glucose carbon metabolism in epilepsy and targeted metabolic treatments. Clinical bioenergetics: from pathophysiology to clinical translation. (pp. 653-677) edited by Sergej Ostojic. London, United Kingdom: Elsevier. doi: 10.1016/b978-0-12-819621-2.00029-2
Tan, Kah Ni, McDonald, Tanya S. and Borges, Karin (2015). Metabolic dysfunctions in epilepsy and novel metabolic treatment approaches. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease: Prevention and Therapy. (pp. 461-470) edited by Ronald R Watson and Victor R Preedy. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/B978-0-12-411462-3.00048-5
Journal Articles
McDonald, Tanya S., Cui, Cedric S., Lerskiatiphanich, Titaya, Marallag, Jianina and Lee, John D. (2025). Metabolic rate and insulin-independent glucose uptake increase in a TDP-43Q331K mouse model of amyotrophic lateral sclerosis. Heliyon, 11 (3) e42482, 1-13. doi: 10.1016/j.heliyon.2025.e42482
McDonald, Tanya S., Lerskiatiphanich, Titaya, Woodruff, Trent M., McCombe, Pamela A. and Lee, John D. (2022). Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disorders. Journal of Cerebral Blood Flow and Metabolism, 43 (1), 26-43. doi: 10.1177/0271678x221135061
McDonald, Tanya S., Neal, Elliott S. and Borges, Karin (2021). Fructose 1,6-bisphosphate is anticonvulsant and improves oxidative glucose metabolism within the hippocampus and liver in the chronic pilocarpine mouse epilepsy model. Epilepsy and Behavior, 122 108223, 1-9. doi: 10.1016/j.yebeh.2021.108223
McDonald, Tanya S., Kumar, Vinod, Fung, Jenny N., Woodruff, Trent M. and Lee, John D. (2021). Glucose clearance and uptake is increased in the SOD1 G93A mouse model of amyotrophic lateral sclerosis through an insulin‐independent mechanism. The FASEB Journal, 35 (7) e21707, e21707. doi: 10.1096/fj.202002450r
Lee, John D., McDonald, Tanya S., Fung, Jenny N. T. and Woodruff, Trent M. (2020). Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1 Mouse Model of Amyotrophic Lateral Sclerosis. Molecular Neurobiology, 57 (10), 4143-4155. doi: 10.1007/s12035-020-02019-9
McDonald, Tanya S., McCombe, Pamela A., Woodruff, Trent M. and Lee, John D. (2020). The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis. The FASEB Journal, 34 (6) fj.201901781, 7225-7233. doi: 10.1096/fj.201901781
McDonald, Tanya, Hodson, Mark P., Bederman, Ilya, Puchowicz, Michelle and Borges, Karin (2019). Triheptanoin alters [U- 13 C 6 ]-glucose incorporation into glycolytic intermediates and increases TCA cycling by normalizing the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase in a chronic epilepsy mouse model. Journal of Cerebral Blood Flow and Metabolism, 40 (3), 271678X19837380-691. doi: 10.1177/0271678X19837380
Durie, Dylan, McDonald, Tanya S. and Borges, Karin (2018). The effect of dichloroacetate in mouse models of epilepsy. Epilepsy Research, 145, 77-81. doi: 10.1016/j.eplepsyres.2018.06.004
McDonald, Tanya, Puchowicz, Michelle and Borges, Karin (2018). Impairments in oxidative glucose metabolism in epilepsy and metabolic treatments thereof. Frontiers in Cellular Neuroscience, 12 274, 274. doi: 10.3389/fncel.2018.00274
McDonald, Tanya S., Carrasco-Pozo, Catalina, Hodson, Mark P. and Borges, Karin (2018). Correction: Alterations in Cytosolic and Mitochondrial [U-13C]Glucose Metabolism in a Chronic Epilepsy Mouse Model (vol 4, e0341-16.2017, 2017). eNeuro, 5 (2). doi: 10.1523/ENEURO.0154-18.2018
McDonald, Tanya S. and Borges, Karin (2017). Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: Reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase. Epilepsia, 58 (7), 1172-1180. doi: 10.1111/epi.13796
McDonald, Tanya S., Carrasco-Pozo, Catalina, Hodson, Mark P. and Borges, Karin (2017). Alterations in cytosolic and mitochondrial [U-13C] glucose metabolism in a chronic epilepsy mouse model. eNeuro, 4 (1) e0341-16.2017, ENEURO.0341-16.2017. doi: 10.1523/ENEURO.0341-16.2017
Tefera, Tesfaye W. , Tan, Kah Ni, McDonald, Tanya S. and Borges, Karin (2016). Alternative fuels in epilepsy and amyotrophic lateral sclerosis. Neurochemical Research, 42 (6), 1-11. doi: 10.1007/s11064-016-2106-7
Tefera, Tesfaye W., Wong, Yide, Barkl-Luke, Mallory E., Ngo, Shyuan T., Thomas, Nicola K., McDonald, Tanya S. and Borges, Karin (2016). Triheptanoin protects motor neurons and delays the onset of motor symptoms in a mouse model of amyotrophic lateral sclerosis. Plos One, 11 (8) e0161816, e0161816. doi: 10.1371/journal.pone.0161816
Tan, Kah Ni, Carrasco-Pozo, Catalina, McDonald, Tanya S., Puchowicz, Michelle and Borges, Karin (2016). Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function. Journal Of Cerebral Blood Flow and Metabolism, 37 (6), 2035-2048. doi: 10.1177/0271678X16659498
Hadera, Mussie Ghezu, McDonald, Tanya, Smeland, Olav B., Meisingset, Tore W., Eloqayli, Haytham, Jaradat, Saied, Borges, Karin and Sonnewald, Ursula (2015). Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-l-Carnitine. Neurochemical Research, 41 (1-2), 86-95. doi: 10.1007/s11064-015-1728-5
Hadera, Mussie G., Smeland, Olav B., McDonald, Tanya S., Tan, Kah Ni, Sonnewald, Ursula and Borges, Karin (2014). Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epileps. Journal of Neurochemistry, 129 (1), 107-119. doi: 10.1111/jnc.12610
McDonald, Tanya S., Tan, Kah Ni, Hodson, Mark P. and Borges, Karin (2014). Alterations of hippocampal glucose metabolism by even versus uneven medium chain triglycerides. Journal Of Cerebral Blood Flow and Metabolism, 34 (1), 153-160. doi: 10.1038/jcbfm.2013.184
Smeland, Olav B., Hadera, Mussie G., McDonald, Tanya S., Sonnewald, Ursula and Borges, Karin (2013). Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice. Journal of Cerebral Blood Flow and Metabolism, 33 (7), 1090-1097. doi: 10.1038/jcbfm.2013.54
Conference Papers
McDonald, Tanya, Hodson, Mark and Borges, Karin (2014). Triheptanoin alters anaplerosis and glutamate production in the chronic pilocarpine model of epilepsy. EB2014: Experimental Biology 2014, San Diago, CA United States, 26-30 April, 2014. Bethesda, MD United States: Federation of American Societies for Experimental Biology.
Smeland, O. B., Hadera, M. G., McDonald, T., Sonnewald, U. and Borges, K. (2013). Mitochondrial metabolic dysfunction and glutamate reduction in the pilocarpine model of temporal lobe epilepsy in mice. 24th Biennial Meeting of the International Society for Neurochemistry and the American Society for Neurochemistry, Cancun Mexico, 20-24 Apr 2013. United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.12186
Thesis
McDonald, Tanya (2018). Energy metabolism in epilepsy: biochemical changes in glucose metabolism and the effects of metabolic treatments in murine seizure models. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/uql.2018.629