Dr Hannah Siddle
Research Fellow/Senior Research officer
Centre for Animal Science
Book Chapter
Cheng, Yuanyuan, Siddle, Hannah V. and Belov, Katherine (2010). The marsupial major histocompatibility complex. Marsupial Genetics and Genomics. (pp. 339-356) edited by Janine E. Deakin, Paul D. Waters and Jennifer A. Marshall Graves. Amsterdam, Netherlands: Springer. doi: 10.1007/978-90-481-9023-2_16
Journal Articles
Santos, John Harvey M., Boe‐Hansen, Gry B., Siddle, Hannah V., Nguyen, Loan T., Raza, Ali, McGowan, Michael, McCosker, Kieren D. and Tabor, Ala E. (2025). Systematic review of vaccine strategies against Tritrichomonas foetus infection in cattle: Insights, challenges, and prospects. Parasite Immunology, 47 (1) e70003, 1-23. doi: 10.1111/pim.70003
Ong, Chian Teng, Blackall, Patrick. J., Boe-Hansen, Gry B., deWet, Sharon, Hayes, Ben J., Indjein, Lea, Korolik, Victoria, Minchin, Catherine, Nguyen, Loan To, Nordin, Yusralimuna, Siddle, Hannah, Turni, Conny, Venus, Bronwyn, Westman, Mark E., Zhang, Zhetao and Tabor, Ala E. (2024). Whole-genome comparison using complete genomes from Campylobacter fetus strains revealed single nucleotide polymorphisms on non-genomic islands for subspecies differentiation. Frontiers in Microbiology, 15 1452564. doi: 10.3389/fmicb.2024.1452564
Juli, Mst Sogra Banu, Boe-Hansen, Gry B., Raza, Ali, Forutan, Mehrnush, Ong, Chian Teng, Siddle, Hannah V. and Tabor, Ala E. (2024). A systematic review of predictive, diagnostic, and prognostic biomarkers for detecting reproductive diseases in cattle using traditional and omics approaches. Journal of Reproductive Immunology, 165 104315, 104315. doi: 10.1016/j.jri.2024.104315
Juli, Mst Sogra Banu, Raza, Ali, Forutan, Mehrnush, Siddle, Hannah V., Fordyce, Geoffry, Muller, Jarud, Boe-Hansen, Gry B. and Tabor, Ala E. (2024). Characterisation of reproductive tract microbiome and immune biomarkers for bovine genital campylobacteriosis in vaccinated and unvaccinated heifers. Frontiers in Microbiology, 15 1404525. doi: 10.3389/fmicb.2024.1404525
Gérard, Anne‐Lise, Owen, Rachel S., Dujon, Antoine M., Roche, Benjamin, Hamede, Rodrigo, Thomas, Frédéric, Ujvari, Beata and Siddle, Hannah V. (2024). In vitro competition between two transmissible cancers and potential implications for their host, the Tasmanian devil. Evolutionary Applications, 17 (3) e13670, e13670. doi: 10.1111/eva.13670
Santos, John Harvey M., Siddle, Hannah V., Raza, Ali, Stanisic, Danielle I., Good, Michael F. and Tabor, Ala E. (2023). Exploring the landscape of Babesia bovis vaccines: progress, challenges, and opportunities. Parasites and Vectors, 16 (1) 274, 1-12. doi: 10.1186/s13071-023-05885-z
Ong, Chrissie E. B., Cheng, Yuanyuan, Siddle, Hannah V., Lyons, A. Bruce, Woods, Gregory M. and Flies, Andrew S. (2022). Class II transactivator induces expression of MHC-I and MHC-II in transmissible Tasmanian devil facial tumours. Open Biology, 12 (10) 220208, 1-13. doi: 10.1098/rsob.220208
Hussey, Kathryn, Caldwell, Alison, Kreiss, Alexandre, Skjødt, Karsten, Gastaldello, Annalisa, Pye, Ruth, Hamede, Rodrigo, Woods, Gregory M. and Siddle, Hannah V. (2022). Expression of the nonclassical MHC Class I, Saha-UD in the transmissible cancer Devil Facial Tumour Disease (DFTD). Pathogens, 11 (3) 351, 1-17. doi: 10.3390/pathogens11030351
Tissot, Sophie, Gérard, Anne-Lise, Boutry, Justine, Dujon, Antoine M., Russel, Tracey, Siddle, Hannah, Tasiemski, Aurélie, Meliani, Jordan, Hamede, Rodrigo, Roche, Benjamin, Ujvari, Beata and Thomas, Frédéric (2022). Transmissible cancer evolution: the under-estimated role of environmental factors in the “Perfect Storm” theory. Pathogens, 11 (2) 241, 1-6. doi: 10.3390/pathogens11020241
Owen, Rachel S., Ramarathinam, Sri H., Bailey, Alistair, Gastaldello, Annalisa, Hussey, Kathryn, Skipp, Paul J., Purcell, Anthony W. and Siddle, Hannah V. (2021). The differentiation state of the Schwann cell progenitor drives phenotypic variation between two contagious cancers. PLoS Pathogens, 17 (11) e1010033, 1-23. doi: 10.1371/journal.ppat.1010033
Gastaldello, Annalisa, Ramarathinam, Sri H., Bailey, Alistair, Owen, Rachel, Turner, Steven, Kontouli, N., Elliott, Tim, Skipp, Paul, Purcell, Anthony W. and Siddle, Hannah V. (2021). The immunopeptidomes of two transmissible cancers and their host have a common, dominant peptide motif. Immunology, 163 (2), 169-184. doi: 10.1111/imm.13307
Hamede, Rodrigo, Madsen, Thomas, McCallum, Hamish, Storfer, Andrew, Hohenlohe, Paul A., Siddle, Hannah, Kaufman, Jim, Giraudeau, Mathieu, Jones, Menna, Thomas, Frédéric and Ujvari, Beata (2021). Darwin, the devil, and the management of transmissible cancers. Conservation Biology, 35 (2), 748-751. doi: 10.1111/cobi.13644
Hamede, Rodrigo, Owen, Rachel, Siddle, Hannah, Peck, Sarah, Jones, Menna, Dujon, Antoine M., Giraudeau, Mathieu, Roche, Benjamin, Ujvari, Beata and Thomas, Frédéric (2020). The ecology and evolution of wildlife cancers: Applications for management and conservation. Evolutionary Applications, 13 (7), 1719-1732. doi: 10.1111/eva.12948
Burr, Marian L., Sparbier, Christina E., Chan, Kah Lok, Chan, Yih-Chih, Kersbergen, Ariena, Lam, Enid Y.N., Azidis-Yates, Elizabeth, Vassiliadis, Dane, Bell, Charles C., Gilan, Omer, Jackson, Susan, Tan, Lavinia, Wong, Stephen Q., Hollizeck, Sebastian, Michalak, Ewa M., Siddle, Hannah V., McCabe, Michael T., Prinjha, Rab K., Guerra, Glen R., Solomon, Benjamin J., Sandhu, Shahneen, Dawson, Sarah-Jane, Beavis, Paul A., Tothill, Richard W., Cullinane, Carleen, Lehner, Paul J., Sutherland, Kate D. and Dawson, Mark A. (2019). An evolutionarily conserved function of polycomb silences the MHC Class I antigen presentation pathway and enables immune evasion in cancer. Cancer Cell, 36 (4), 385-401.e8. doi: 10.1016/j.ccell.2019.08.008
James, Samantha, Jennings, Geordie, Kwon, Young Mi, Stammnitz, Maximilian, Fraik, Alexandra, Storfer, Andrew, Comte, Sebastien, Pemberton, David, Fox, Samantha, Brown, Bill, Pye, Ruth, Woods, Gregory, Lyons, Bruce, Hohenlohe, Paul A., McCallum, Hamish, Siddle, Hannah, Thomas, Frédéric, Ujvari, Beata, Murchison, Elizabeth P., Jones, Menna and Hamede, Rodrigo (2019). Tracing the rise of malignant cell lines: Distribution, epidemiology and evolutionary interactions of two transmissible cancers in Tasmanian devils. Evolutionary Applications, 12 (9), 1772-1780. doi: 10.1111/eva.12831
Owen, Rachel S. and Siddle, Hannah V. (2019). Devil facial tumours: towards a vaccine. Immunological Investigations, 48 (7), 719-736. doi: 10.1080/08820139.2019.1624770
Kosack, Lindsay, Wingelhofer, Bettina, Popa, Alexandra, Orlova, Anna, Agerer, Benedikt, Vilagos, Bojan, Majek, Peter, Parapatics, Katja, Lercher, Alexander, Ringler, Anna, Klughammer, Johanna, Smyth, Mark, Khamina, Kseniya, Baazim, Hatoon, de Araujo, Elvin D., Rosa, David A., Park, Jisung, Tin, Gary, Ahmar, Siawash, Gunning, Patrick T., Bock, Christoph, Siddle, Hannah V., Woods, Gregory M., Kubicek, Stefan, Murchison, Elizabeth P., Bennett, Keiryn L., Moriggl, Richard and Bergthaler, Andreas (2019). The ERBB-STAT3 axis drives Tasmanian devil facial tumor disease. Cancer Cell, 35 (1), 125-139.e9. doi: 10.1016/j.ccell.2018.11.018
Caldwell, Alison, Coleby, Rachel, Tovar, Cesar, Stammnitz, Maximilian R., Mi Kwon, Young, Owen, Rachel S., Tringides, Marios, Murchison, Elizabeth P., Skjødt, Karsten, Thomas, Gareth J., Kaufman, Jim, Elliott, Tim, Woods, Gregory M. and Siddle, Hannah V. T. (2018). The newly-arisen devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer. eLife, 7 e35314, 1-18. doi: 10.7554/eLife.35314
Stammnitz, Maximilian R., Coorens, Tim H.H., Gori, Kevin C., Hayes, Dane, Fu, Beiyuan, Wang, Jinhong, Martin-Herranz, Daniel E., Alexandrov, Ludmil B., Baez-Ortega, Adrian, Barthorpe, Syd, Beck, Alexandra, Giordano, Francesca, Knowles, Graeme W., Kwon, Young Mi, Hall, George, Price, Stacey, Pye, Ruth J., Tubio, Jose M.C., Siddle, Hannah V. T., Sohal, Sukhwinder Singh, Woods, Gregory M., McDermott, Ultan, Yang, Fengtang, Garnett, Mathew J., Ning, Zemin and Murchison, Elizabeth P. (2018). The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils. Cancer Cell, 33 (4), 607-619.e15. doi: 10.1016/j.ccell.2018.03.013
Caldwell, Alison and Siddle, Hannah V. (2017). The role of MHC genes in contagious cancer: the story of Tasmanian devils. Immunogenetics, 69 (8-9), 537-545. doi: 10.1007/s00251-017-0991-9
Siddle, H. V. (2017). Cancer as a contagious disease. HLA, 89 (4), 209-214. doi: 10.1111/tan.12980
Tovar, Cesar, Pye, Ruth J., Kreiss, Alexandre, Cheng, Yuanyuan, Brown, Gabriella K., Darby, Jocelyn, Malley, Roslyn C., Siddle, Hannah V. T., Skjodt, Karsten, Kaufman, Jim, Silva, Anabel, Morelli, Adriana Baz, Papenfuss, Anthony T., Corcoran, Lynn M., Murphy, James M., Pearse, Martin J., Belov, Katherine, Lyons, A. Bruce and Woods, Gregory M. (2017). Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils. Scientific Reports, 7 (1) 43827, 1-14. doi: 10.1038/srep43827
Pye, Ruth, Hamede, Rodrigo, Siddle, Hannah V., Caldwell, Alison, Knowles, Graeme W., Swift, Kate, Kreiss, Alexandre, Jones, Menna E., Lyons, A Bruce and Woods, Gregory M. (2016). Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils. Biology Letters, 12 (10) 20160553, 1-5. doi: 10.1098/rsbl.2016.0553
Pye, Ruth J., Pemberton, David, Tovar, Cesar, Tubio, Jose M. C., Dun, Karen A., Fox, Samantha, Darby, Jocelyn, Hayes, Dane, Knowles, Graeme W., Kreiss, Alexandre, Siddle, Hannah V. T., Swift, Kate, Lyons, A. Bruce, Murchison, Elizabeth P. and Woods, Gregory M. (2016). A second transmissible cancer in Tasmanian devils. Proceedings of the National Academy of Sciences of the United States of America, 113 (2), 374-379. doi: 10.1073/pnas.1519691113
Siddle, Hannah V. and Kaufman, Jim (2015). Immunology of naturally transmissible tumours. Immunology, 144 (1), 11-20. doi: 10.1111/imm.12377
Siddle, Hannah V. and Kaufman, Jim (2013). How the devil facial tumor disease escapes host immune responses. OncoImmunology, 2 (8) e25235. doi: 10.4161/onci.25235
Siddle, Hannah V. and Kaufman, Jim (2013). A tale of two tumours: comparison of the immune escape strategies of contagious cancers. Molecular Immunology, 55 (2), 190-193. doi: 10.1016/j.molimm.2012.10.017
Siddle, Hannah V., Kreiss, Alexandre, Tovar, Cesar, Yuen, Chun Kit, Cheng, Yuanyuan, Belov, Katherine, Swift, Kate, Pearse, Anne-Maree, Hamede, Rodrigo, Jones, Menna E., Skjodt, Karsten, Woods, Gregory M. and Kaufman, Jim (2013). Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer. Proceedings of the National Academy of Sciences of the United States of America, 110 (13), 5103-5108. doi: 10.1073/pnas.1219920110
Cheng, Yuanyuan, Stuart, Andrew, Morris, Katrina, Taylor, Robyn, Siddle, Hannah, Deakin, Janine, Jones, Menna, Amemiya, Chris T. and Belov, Katherine (2012). Antigen-presenting genes and genomic copy number variations in the Tasmanian devil MHC. BMC Genomics, 13 (87) 87. doi: 10.1186/1471-2164-13-87
Siddle, Hannah V., Deakin, Janine E., Coggill, Penny, Whilming, Laurens, Harrow, Jennifer, Kaufman, Jim, Beck, Stephan and Belov, Katherine (2011). The tammar wallaby major histocompatibility complex shows evidence of past genomic instability. BMC Genomics, 12 421. doi: 10.1186/1471-2164-12-421
Renfree, Marilyn B., Papenfuss, Anthony T., Deakin, Janine E., Lindsay, James, Heider, Thomas, Belov, Katherine, Rens, Willem, Waters, Paul D., Pharo, Elizabeth A., Shaw, Geoff, Wong, Emily S. W., Lefevre, Christopher M., Nicholas, Kevin R., Kuroki, Yoko, Wakefield, Matthew J., Zenger, Kyall R., Wang, Chenwei, Ferguson-Smith, Malcolm, Nicholas, Frank W., Hickford, Danielle, Yu, Hongshi, Short, Kirsty R., Siddle, Hannah V., Frankenberg, Stephen R., Chew, Keng Yih, Menzies, Brandon R., Stringer, Jessica M., Suzuki, Shunsuke, Hore, Timothy A. ... Worley, Kim C. (2011). Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development. Genome Biology, 12 (8) R81, R81.1-R81.25. doi: 10.1186/gb-2011-12-8-r81
Siddle, Hannah V., Marzec, Jolanta, Cheng, Yuanyuan, Jones, Menna and Belov, Katherine (2010). MHC gene copy number variation in Tasmanian devils: Implications for the spread of a contagious cancer. Proceedings of the Royal Society B-Biological Sciences, 277 (1690), 2001-2006. doi: 10.1098/rspb.2009.2362
Cheng, Yuanyuan, Siddle, Hannah V., Beck, Stephan, Eldridge, Mark D. B. and Belov, Katherine (2009). High levels of genetic variation at MHC class II DBB loci in the tammar wallaby (Macropus eugenii). Immunogenetics, 61 (2), 111-118. doi: 10.1007/s00251-008-0347-6
Siddle, Hannah V., Deakin, Janine E., Coggill, Penny, Hart, Elizabeth, Cheng, Yuanyuan, Wong, Emily S. W., Harrow, Jennifer, Beck, Stephan and Belov, Katherine (2009). MHC-linked and un-linked class I genes in the wallaby. BMC Genomics, 10 (1) 310, 1-15. doi: 10.1186/1471-2164-10-310
Cheng, Yuanyuan, Wakefield, Matthew, Siddle, Hannah V., Coggill, Penny C., Herbert, Cathy A., Beck, Stephan, Belov, Katherine and Eldridge, Mark D. B. (2009). Isolation and characterization of 10 MHC Class I-associated microsatellite loci in tammar wallaby (Macropus eugenii). Molecular Ecology Resources, 9 (1), 346-349. doi: 10.1111/j.1755-0998.2008.02401.x
Siddle, Hannah V., Kreiss, Alexandre, Eldridge, Mark D. B., Noonan, Erin, Clarke, Candice J., Pyecroft, Stephen, Woods, Gregory M. and Belov, Katherine (2007). Transmission of a fatal clonal tumor by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupial. Proceedings of the National Academy of Sciences of the United States of America, 104 (41), 16221-16226. doi: 10.1073/pnas.0704580104
Siddle, Hannah V., Sanderson, Claire and Belov, Katherine (2007). Characterization of major histocompatibility complex class I and class II genes from the Tasmanian devil (Sarcophilus harrisii). Immunogenetics, 59 (9), 753-760. doi: 10.1007/s00251-007-0238-2
Woods, Gregory M., Kreiss, Alexandre, Belov, Katherine, Siddle, Hannah V., Obendorf, David L. and Muller, H. Konrad (2007). The immune response of the Tasmanian devil (Sarcophilus harrisii) and devil facial tumour disease-t. EcoHealth, 4 (3), 338-345. doi: 10.1007/s10393-007-0117-1
Deakin, J. E., Siddle, H. V., Cross, J. G.R., Belov, K. and Graves, J. A.M. (2007). Class I genes have split from the MHC in the tammar wallaby. Cytogenetic and Genome Research, 116 (3), 205-211. doi: 10.1159/000098188
Siddle, Hannah V., Deakin, Janine E., Baker, Michelle L., Miller, Robert D. and Belov, Katherine (2006). Isolation of major histocompatibility complex Class I genes from the tammar wallaby (Macropus eugenii). Immunogenetics, 58 (5-6), 487-493. doi: 10.1007/s00251-006-0107-4
Belov, Katherine, Deakin, Janine E., Papenfuss, Anthony T., Baker, Michelle L., Melman, Sandra D., Siddle, Hannah V., Gouin, Nicolas, Goode, David L., Sargeant, Tobias J., Robinson, Mark D., Wakefield, Matthew J., Mahony, Shaun, Cross, Joseph G. R., Benos, Panayiotis V., Samollow, Paul B., Speed, Terence P., Marshall Graves, Jennifer A. and Miller, Robert D. (2006). Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex. PLoS Biology, 4 (3) 46, 0317-0328. doi: 10.1371/journal.pbio.0040046
Conference Paper
Tabor, Ala, Siddle, Hannah, Juli, Sogra Banu, Raza, Ali, Ong, Chian Teng, McCosker, Kieren, Hayes, Ben and Boe-Hansen, Gry (2023). New diagnostic tools for bovine vibriosis. Northern Beef Research Update Conference, Darwin, NT Australia, 22-25 August 2023.